New bisbenzylisoquinoline alkaloid, isolation and structure elucidation from Cocculus pendulus

Abstract

This paper describes phytochemical studies on aerial part of the Cocculus pendulus, which led to the identification of a new ingredient namely, 2 N-methylkohatine (1) along with four reported compounds Kohatine (2), 1,2-Dehydrokohatine (3) and 5′Hhydroxyapateline (4). Structures of the all Compounds were elucidated by using 1 D and 2 D NMR and mass spectroscopy furthermore the structure of new Compound 1 was also proved by synthesize from compound 2 (Kohatine).

Graphical Abstract

Keywords:

• Bisbenzylisoquinoline alkaloids
• 2N-methylkohatine
• Kohatine
• Cocculus pendulus

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.