https://orcid.org/0000-0002-1230-8323
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Abstract
Two new tigliane- and daphnane-type diterpenoids, given the trivial names daphnegens A–B (1–2) were isolated from the buds of Daphne genkwa. Their structures were assigned on the basis of extensive spectroscopic. The absolute configurations of both compounds were determined by comparison of their calculated and experimental CD curves. In addition, compounds 1–2 were tested for their cytotoxic activities against MCF-7 and HepG-2 human cancer cell lines, and compound 2 showed remarkable cytotoxic activity against HepG-2 cell line with the IC50 value of 11.5 μM.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
This work was supported by the Foundation of Key Cultivation Project of Qiqihar Academy of Medical Sciences, China [grant number 2022-ZDPY-002], Natural Science Foundation of Heilongjiang Province, China [grant number LH2019H127], the Foundation of Qiqihar Science and Technology Joint Guidance Project, China [grant number LHYD-2021026].