https://orcid.org/0000-0002-4647-9905
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Abstract
Three new steroids (1–3) and 13 reported analogs (4–16) were extracted from Datura metel L. pericarps. Structure analysis of these extracted compounds was performed by 1 D-NMR and 2 D-NMR spectroscopy, and their spectra were compared with those of similar compounds previously described in the literature. The extracted steroids (1–3) and known compounds (4–16) were evaluated for anti-inflammatory activity against LPS-activated RAW 264.7 cells. Compounds 5, 7, 9, 12 and 15 showed potential anti-inflammatory activity with IC50 less than 35 μM, while compounds 3 and 11 showed weak anti-inflammatory activity with IC50 less than 100 μM.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was supported by the Heilongjiang Touyan Innovation Team Program, National Natural Science Foundation of China (NSFC) (81903781, 81773883), National Key Research and Development Project (2018YFC1707100), China Postdoctoral Science Foundation (2018M631978), Excellent Youth Project of Heilongjiang Natural Science Foundation (YQ2019H029), Heilongjiang University of Chinese Medicine Founds (2018pt01, 2018bs03), and Innovative Research Project for Graduate Students of Heilongjiang University of Chinese Medicine (2020yjscx009).