New sesquiterpene from a soil fungus of Trichoderma sp

Abstract

Sixteen secondary metabolites, including one new sesquiterpene (1, named isocyclonerodiol oxide), seven known sesquiterpenes (2–8), two sorbicillinoid polyketides (15, 16), and six known other compounds (9–14) were isolated from the fermentation broth of Trichoderma sp. T-4-1. The structure of 1 was determined by 1 D, 2 D NMR (HMBC, HSQC, ¹H-¹H COSY, NOESY), and HRESIMS spectra. In addition, sesquiterpenes and sorbicillinoid polyketides showed significant antiviral activities.

Graphical Abstract

Keywords:

• Antiviral activity
• sesquiterpenoids
• soil fungus
• Trichoderma sp.

Disclosure statement

No conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the funding from the National Natural Science Foundation of China (81773556), Science and Technology Department of Guangdong Province of China (2022A1515010182 and 2015A020211010), and Southern Medical University (B1040903).