Phenolic and bisamide derivatives from Aglaia odorata and their biological activities

Abstract

Three new compounds (1–3), including two bisamide derivatives (1 and 2) and a lignin (3), along with 15 known compounds were isolated from Aglaia odorata. Compound 2 was a pair of enantiomers and successfully resolved into the anticipated enantiomers. Their structures were elucidated by extensive spectroscopic analysis, electronic circular dichroism (ECD) calculations, and X-ray crystallography. Three compounds showed excellent inhibitory activities on α-glucosidase with IC₅₀ values ranging from 54.48 to 240.88 μM, better than that of the positive control (acarbose, IC₅₀ = 590.94 μM). Moreover, compounds 3, 13, and 15 presented moderate inhibitory activities against butyrylcholinesterase. Compound 17 exhibited potent PTP1B inhibitory activity with an IC₅₀ value of 179.45 μM. Representative active compounds were performed for the molecular docking study. Herein, we described the isolation, structure elucidation, the inhibitory effects on three enzymes, and molecular docking of the isolates from the title plant.

Graphical Abstract

Keywords:

• Aglaia odorata
• chemical constituents
• α-glucosidase
• butyrylcholinesterase
• protein tyrosine phosphatase 1B
• molecular docking

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Sciences Foundation of China (No. 31960087, 82060631, and 81760630), the Science and Technology Department of Guizhou Province (QKH JC [2020]1Y400), High-level Innovative Talents in Guizhou Province (Thousand Levels of Talent for Chunmao Yuan in 2018), ‘Light of the West’, Talent Cultivation Program of Chinese Academy of Sciences for Chunmao Yuan (RZ [2020]82), the 13th batch of outstanding young scientific and technological talents in Guizhou Province (QKHPTRC [2021]5633), and Guizhou Provincial Engineering Research Center for Natural Drugs.