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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 14
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Research Article

New cembranoids from the leaves and twigs of Croton yanhuii Y. T. Chang

Daidi Zhanga Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, ChinaView further author information
,
Didi Wanga Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China;b School of Pharmacy, Guizhou Medical University, Guiyang, ChinaView further author information
,
Zhenwei Lia Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China;c Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;d University of Chinese Academy of Sciences, Beijing, ChinaView further author information
,
Dean Guoa Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China;c Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;d University of Chinese Academy of Sciences, Beijing, ChinaCorrespondence[email protected]
View further author information
&
Wei Lia Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China;c Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;d University of Chinese Academy of Sciences, Beijing, ChinaCorrespondence[email protected]
View further author information
Pages 2380-2386 | Received 01 Nov 2022, Accepted 23 Jan 2023, Published online: 10 Feb 2023
 
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Abstract

Crotonyanes A (1) and B (2), two new cembranoids were isolated from the leaves and twigs of Croton yanhuii Y. T. Chang. Their structures were elucidated by extensive spectroscopic analyses and quantum chemical calculations. Bioassays verified that compound 1 exhibited an inhibitory effect on nitric oxide (NO) production in RAW 264.7 cells, with an IC50 value of 30.6 ± 4.3 µM.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Natural Science Foundation of China (No. 82104020), High-level New R&D Institute of Department of Science and Technology of Guangdong Province (No. 2019B090904008), and High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province (No. 2021B0909050003).

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