Phytochemical screening and radioprotective potential of Jasminum grandiflorum methanol extract against gamma irradiation-induced oxidative damage and diverse inflammatory mediators in lungs of male Swiss Albino Rats

Abstract

Rising awareness about the ecological burden of agricultural by-products and their potential industrial and medicinal applications spurred the research of waste valorization. Egypt is a chief producer of jasmine oils. However, jasmine-dense foliage is an agricultural waste that merits exploitation. Herein, Jasminum grandiflorum leaves were profiled using UPLC-MS, revealing a promising phytochemical composition rich in secoiridoids. A good safety profile was confirmed in vitro on cancerous and normal cell lines and in vivo (LD₅₀>4000mg/kg). The radioprotective effect of 3500 mg/kg jasmine leaves extract against irradiation-induced lung injury was demonstrated. Biochemical analysis indicated that jasmine extract decreased malondialdehyde level and enhanced the endogenous antioxidants GSH-Px, SOD and CAT levels. Jasmine alleviated the inflammatory response by downregulating the expression of COX-2 and iNOS and reducing the inflammatory mediators, TNF-α, IL-6, NO, and PGE2. Jasmine leaves offer interesting application prospects that add economic and industrial value to agricultural waste.

Graphical abstract

Keywords:

• Jasminum grandiflorum
• UPLC-MS
• radioprotective
• antioxidant
• anti-inflammatory
• rat lung

Disclosure statement

The authors report there are no competing interests to declare.

Additional information

Funding

The authors would like to thank the research sector of Ain Shams University, Cairo, Egypt (Number M/78/1) for providing partial funding for this work.