Cytotoxic pyrone derivatives from the deep-sea-derived fungus Cladosporium halotolerans FS702

Abstract

Two new compounds (R)-6-((8S)-hydroxypropyl)-2-methyl-5,6-dihydro-4H-pyran-4-one (1) and (R)-6-((8R)-hydroxypropyl)-2-methyl-5,6-dihydro-4H-pyran-4-one (2), together with four known compounds were isolated from the marine-derived fungus Cladosporium halotolerans FS702. The structures of these compounds were determined on the basis of extensive spectroscopic analysis including 1D/2D NMR, IR, UV, HRESIMS, ECD calculations as well as the modified Mosher’s method. Cytotoxic assay results showed that compound 2 had significant cytotoxic activity against SF-268, MCF-7, HepG-2, and A549 cells lines with IC₅₀ values of 0.16, 0.47, 0.33 and 0.23 µM, respectively.

GRAPHICAL ABSTRACT

Keywords:

• marine-derived fungus
• Cladosporium halotolerans
• cytotoxic activity

Acknowledgments

We sincerely thank the Computing Center of the Chinese Academy of Science, and Ms. Ai-Jun Sun, Yun Zhang and Xuan Ma of the South China Sea Institute of Oceanology, and the Chinese Academy of Sciences, for the measurement of HRESIMS and CD.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Guangdong Special Support Program (2019TQ05Y375), Guangdong Provincial Special Fund for Marine Economic Development Project ([2021]054), and Guangdong Provincial Project for Science and Technology (No. 2021A1515011549). Data and samples were collected onboard of R/V "JiaGeng" implementing the open research cruise NORC2019-06 and NORC2020-06 supported by NSFC Shiptime Sharing Project (41849906 and 41949906).