https://orcid.org/0000-0002-0732-3377
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Abstract
Two new prenylated flavonoids named sinoflavonoids NJ and NK (1–2), along with ten known compounds were isolated from the fruits of Podophyllum hexandrum Royle. The chemical structures were determined through NMR spectroscopic data and MS analysis. Sinoflavonoid NJ (1) with an unusual 5,11-dioxabenzo[b]fluoren-10-one skeleton was firstly reported from Berberidaceae. The isolated flavonoids were tested with LPS-induced RAW 264.7 mouse macrophages model for their anti-inflammatory activity. Sinoflavonoid NJ (1) showed the most potent inhibition on nitric oxide production with IC50 value as 0.06 μM.
GRAPHICAL ABSTRACT
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This research was financially supported by the National Pharmacopoeia Standard Improvement Project (No.2019Z088) and the Jiangsu Provincial Innovation and Entrepreneurship Talent Plan (202010528).