Two new cyclopeptides from Stachys geobombycis C. Y. Wu

Abstract

Two new cyclic peptides, named as cyclogeobomptides A (1) and B (2) were isolated from the roots of Stachys geobombycis C. Y. Wu. Compounds 1 and 2 are both made up of eight amino acids. The structures of them were established on the basis of the spectral data, including mass spectrometry, 2D NMR, and X-ray crystallography. Cyclogeobomptides A and B were proved to have obvious inhibitory activities against α-glucosidase with the IC₅₀ values of 26.00 and 19.16 μM, respectively.

Graphical Abstract

Keywords:

• Stachys geobombycis C. Y. Wu
• cyclopeptide
• α-glucosidase

Acknowledgement

We are grateful to Guangxi Normal University for measuring the UV, MS and NMR spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (No. 81860621) and the Natural Science Foundation of Guangxi Province (No. 2018GXNSFBA281032).