https://orcid.org/0000-0001-8327-3108
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Abstract
Chemical investigation of the Penicillium sp. SCSIO 41038 led to the isolation and characterization of one new cyclopiazonic acid-type alkaloid, speradine I (1), and one new phloroglucinol derivative, speradine J (8), along with 13 known compounds. Their structures were determined on the basis of extensive spectroscopic analysis, and by a comparison with data from the literature. All the compounds were evaluated for their antitumor (22Rv1 and PC-3) and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro.
Graphical Abstract
Acknowledgements
We are grateful to Dr. Z. Xiao, A. Sun, X. Zhen, X. Ma, S. Dai, and Y. Zhang in the analytical facility at SCSIO for recording spectroscopic data.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was supported by grants from the National Natural Science Foundation of China (21977102, 42276128, 81860626, 81973235, 82073762) and Guangdong Basic and Applied Basic Research Foundation (2021B1515120046, 2019B151502042, 2020A1515011045).