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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 6
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Research Articles

Glycosides with galloyl groups from Balakata baccata and their antineuroinflammatory activities

Hai-Yan Zhaoa State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People’s Republic of China;c College of Food and Biochemical Engineering, Guangxi Science & Technology Normal University, Laibin, People’s Republic of ChinaView further author information
,
Shuang Hea State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People’s Republic of ChinaView further author information
,
Qian Lana State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People’s Republic of ChinaView further author information
,
Bao-Jun Sua State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People’s Republic of ChinaView further author information
,
Heng-Shan Wanga State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People’s Republic of ChinaView further author information
&
Dong Lianga State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People’s Republic of China;b State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Pages 947-955 | Received 08 Oct 2022, Accepted 17 Apr 2023, Published online: 05 May 2023
 
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Abstract

Seven new glycosides (1 − 7) with galloyl groups and two known kaempferol glycosides (8 and 9) were obtained from the overground parts of Balakata baccata. The structures of the new compounds were determined by comprehensive spectroscopic analyses. The rarely seen allene moiety in compounds 6 and 7 were described by detailed analysis of 1D and 2D NMR data. The antineuroinflammatory effect of all the isolates was assessed through inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-induced BV-2 microglial cells. Compounds 1, 2, 6, and 7 showed potent inhibitory activities with IC50 values of 25.7, 17.2, 15.5 and 24.4 μM, respectively, compared with the positive control minocycline (IC50 = 16.1 μM).

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported partially by the National Natural Science Foundation of China (22177021 and 81960634) and the State Key Laboratory of Medicinal Chemical Biology (2022010).

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