Aralianudaside A, an unusual skeleton triterpenoid saponin with anti-airway inflammatory activity from Aralia elata

Abstract

Aralianudaside A, a triterpene saponin with an unusual skeleton of pentacyclic triterpenoid, along with a new triterpene glycoside and six known compounds were obtained from the buds of Aralia elata. Their structures were determined through extensive spectral analysis, including HRESIMS, IR, 1D and 2D NMR, glycolysis and GC. All compounds were evaluated for anti-airway inflammatory activity in lipopolysaccharides (LPS)-induced airway epithelial cells (16HBE), compounds 1, 3, 5, 7 and 8 significantly decreased the expression of pro-inflammatory cytokines IL-1β and IL-4.

Graphical Abstract

Keywords:

• Aralia elata
• triterpene saponins
• Aralianudaside A
• Aralianudaside B
• anti-airway inflammatory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by National Natural Science Foundation of China (No. 81860760; 82260832), Science and Technology Programs of Yunnan Province (No. 2019FB117; 202101AZ070001-159), Key Industrial Projects founded by Yunnan Province (No. 202002AA100007), Yunnan Key Laboratory of Southern Medicinal Utilization (No. 202105AG070012).