A new anti-neuroinflammation labdane diterpenoid from Salvia tricuspis

Abstract

One new labdane diterpenoid, tricuspion A (1), as well as five known triterpenoids (2–6) were isolated from Salvia tricuspis Franch (family Labiatae). The structure of tricuspion A was identified by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 1–6 were evaluated for their inhibitory effects on the NO production in LPS-stimulated BV-2 microglia cells, and 1 exhibited potent inhibitory activity with IC₅₀ value of 14.92 ± 0.51 μM. Compound 1 might exert anti-neuroinflammatory activity through inhibiting the excessive production of NO and down-regulating the protein expression of iNOS and COX-2. As such, labdane diterpenoid (tricuspion A) could provide promising anti-neuroinflammatory lead compound for further structural modification.

GRAPHICAL ABSTRACT

Keywords:

• Labdane diterpenoid
• expression of nitric oxide synthase
• expression of cyclooxygenase-2
• anti-neuroinflammatory activity
• Salvia tricuspis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the financial support of the National Natural Science Foundation of China (No. 32070388) and the Scientific Research Foundation of Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan (APR202201).