5-nitro isatin containing heterocyclics derivatives: synthesis, antioxidant activity, anticancer activity and molecular docking

Abstract

The manuscript describes the synthesis of eight Novel 1,2,4-triazine and 1,2-diazino derivatives having the 5-nitro isatin moiety. Antiradical and anticancer activities were evaluated using the DPPH method and the MTT assay against breast cancer (MCF-7) cell lines. The compound with the strongest antioxidant and anticancer properties after 24 h was compound 9 (1,2,4-triazine-3-thione) but after 48 h, compound 7 (1,2,4- triazine-3-ol) with good anticancer activity while compound 11 (1,2-diazino) after 72 h.

Graphical Abstract

Keywords:

• 5-nitro isatin
• 1,2,4-triazine
• diazino
• pyridazine
• anticancer

Acknowledgment

The authors acknowledge Department of Chemistry, College of Science, University of Baghdad for provide all chemicals and some instruments. Ruqaya Mohamed Al-ezzy, College of biotechnology, Al-Nahrain university.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.