Ligulariatinside A, a new sesquiterpene glycoside from roots of Ligularia veitchiana

Abstract

A new sesquiterpene glycoside, ligulariatinside A (1), along with nine known compounds, dibutyl phthalate (2), 1-O-(9Z,12Z-octadecadienoyl) glycerol (3), bis (2-ethylhexyl) phthalate (4), 4-hydroxy-3-methoxyphenylpropanol (5), dihydrosyringenin (6), caffeic acid (7), 6β-hydroxy-7(11)-eremophilen-12,8α-olide (8), together with the mixture of 6β,8β-dihydroxyeremophil-7(11)-en-12,8α-olide (9) and 6β,8α-dihydroxy-eremophil-7(11)-en-12,8β-olide (10) were isolated from roots of L. veitchiana. Structures of these compounds were elucidated by comprehensive analyses of HRESIMS, 1D NMR, and 2D NMR spectroscopic data. Compounds 2 and 4 are not likely natural compounds but contaminants. All isolated compounds were tested for antibacterial activity. Compounds 1, 5, 6, together with the mixture of 9 and 10, showed mild activity against Vibrio anguillarum, with MIC values of 50, 50, 100, and 200 μg/mL, while compound 7 showed moderate activity against Vibrio anguillarum, with a MIC value of 25 μg/mL.

Graphical Abstract

Keywords:

• Ligularia veitchiana
• sesquiterpene glycoside
• antibacterial

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Discipline Innovation and Talent Introduction Program for Higher Education Institutions [D20015], and Scientific Research Project funded by Hubei Education Department under Grant [Q20161207], together with Hubei Key Laboratory of Natural Products Research and Development 2022 Open Fund [2022NPRD07].