New prenyl flavanone and diarylbutanol from Uvaria siamensis stem bark and their α-glucosidase inhibitory activity

Abstract

One new prenyl flavanone (1), (2S)-8-prenyl-5,6-dihydroxy-7-methoxyflavanone, and one new diarylbutanol (2), (7′S)-3′-hydroxy­linderagatin-A, were isolated from the stem bark of Uvaria siamensis (Annonaceae), along with five known compounds, eriodictyol (3), quercetin (4), paprazine (5), N-trans-caffeoyltyramine (6), and N-trans-feruloyltyramine (7). Their structures were determined through extensive spectroscopic analyses and comparison with the literature. The α-glucosidase inhibitory potential of 1-7 was evaluated. Compound 6 showed the highest inhibitory activity against α-glucosidase and exhibited superior potency compared to the positive control, with an IC₅₀ value of 0.12 μM.

Graphical Abstract

Keywords:

• Annonaceae
• Uvaria siamensis
• (2S)-8-prenyl-5,6-dihydroxy-7-methoxyflavanone
• (7’S)-3′-hydroxylinderagatin-A
• α-glucosidase inhibition

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The authors gratefully acknowledge the financial support provided by Faculty of Science and Technology, Contract No. SciGR 2/2566.