Chemical composition and biological activities of essential oil from Grewia bulot leaves

Abstract

This study focused on the chemical composition and biological activities of the essential oil derived from Grewia bulot, a plant species known for its medicinal properties. The analysis of Grewia bulot essential oil revealed the presence of 78 constituents. The major compounds were α-cadinol (13.5%), 1,8-cineole (12.7%), 1,10-di-epi-cubenol (9.8%), epi-α-cadinol (6.7%), (E,E)-α-farnesene (5.9%), (E)-citral (4.0%), selin-11-en-4-α-ol (4.0%), citronellol isobutanoate (3.9%), and geranic acid (3.7%). The essential oil exhibited promising antioxidant potential with an IC₅₀ value of 452.65 ± 28.40 µg/mL in DPPH model. This oil did not show NO production inhibitory effect in RAW 264.7 cells. In addition, the essential oil exhibited significant cytotoxicity against KB, Hep-G2, MCF-7, and SK-LU-1 cancer cell lines, with IC₅₀ values ranging from 44.04 ± 1.47 to 74.20 ± 3.71 μg/mL.

Graphical Abstract

Keywords:

• Grewia bulot
• essential oil
• GC-MS
• antioxidant
• anti-inflammatory
• anticancer

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research is funded by Ministry of Education and Training under grant [number B2022-DHH-13] and the partial support of Hue University under the Core Research Program, Grant [No. NCM.DHH.2023.02].