In vitro and in silico study of eggplant extract on human cancer cell lines

Abstract

The aim of this research was to study the metabolite composition, antioxidative potential and cytotoxic activities of Solanum melongena fruit extracts. Phytochemical analyses of extracts were performed using LC-MS. Phenolic compounds were the major constituents present in the fruit extracts. Free radical scavenging activities were recorded and the highest activities were reported in methanolic extracts using DPPH (103.70 ± 2.75 EC₅₀ μg/mL), ABTS (81.74 ± 3.64 EC₅₀ μg/mL), and FRAP (22.39 ± 1.52 μmol TE/g) assays. Quantification has suggested the presence of delphinidin derivatives, and caffeic acid conjugates as major constituents of fruit extracts. The potential binding of these derivatives with human cell surface receptors was analysed using in silico analysis and validated for cytotoxic and apoptotic effects using in vitro studies on human cancer cell lines. The methanolic extract has shown the highest cytotoxic activity.

Graphical Abstract

Keywords:

• Solanum melongena
• bioactive components
• molecular docking
• phytochemistry
• human cancer cell lines

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data used to support the findings of this study are included in the article.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.