4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity

Abstract

Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined with high-resolution ESIMS data. Compounds 1-4 were assayed to MCF-7 and HeLa cells for their cytotoxic activity. Mesulepidotin A (1) showed high activity with an IC₅₀ value of 1.59 and 1.41 µM, respectively.

Graphical Abstract

Keywords:

• Mesua lepidota
• mesulepidotins A-C
• 4-Phenylcoumarin
• 4-Propylcoumarin
• cytotoxic

Disclosure statement

Every member of the research team stated no conflicts of interest.

Supplementary material

The NMR and HRESIMS data for interpreting the structures of mesulepidotins A-C are attached in the supplementary materials in Figures S1–S21.

Additional information

Funding

The Research was supported by the Directorate General of Research Technology and Higher Education (Penelitian Fundamental Grant, No. 1304/UN.3.LPPM/PT.01.03/2023: Universitas Airlangga, Surabaya).