Phytochemical study, antioxidant and tyrosinase inhibitory activities of Pentzia monodiana Maire

Abstract

Chemical investigation of the aerial parts of Pentzia monodiana Maire led to the isolation and identification of one sesquiterpene lactone glucoside of the guaianolide type (dihydropseudoivalin-4-O-β-d-glucopyranoside), along with nine known compounds including one diterpenoid, two sesquiterpenoids, three lignanes and three flavonoids. Their structures were established on the basis of spectroscopic analysis. All these compounds were evaluated for their DPPH radical scavenging and tyrosinase inhibitory activities. Only lignanes and flavonoids showed good to moderate DPPH radical scavenging activity with EC₅₀ ranging from 10.6 to 47.5 μM. The new sesquiterpene lactone glucoside showed low tyrosinase inhibitory activity whereas the isolated lignanes and flavonoids exhibited a moderate activity with IC₅₀ ranging from 45.4 to 97.2 μM).

Graphical Abstract

Keywords:

• Pentzia monodiana
• Asteraceae
• antioxidant
• antityrosinase

Acknowledgements

The authors are grateful to the Ministry of Higher Education and Scientific Research of Algeria, university Frères Mentouri-Constantine, Conseil Regional Champagne Ardenne, Conseil General de la Marne, Ministry of Higher Education and Research (MESR) and to the PlANET CPER project for financial support.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.