Chemical compounds from Osmunda japonica and their NO inhibitory activity

Abstract

Two new compounds, osmjapterpenoid A (1) and osmunjaponin A (2), along with twenty-six known compounds, were isolated from the roots and rhizomes of Osmunda japonica Thunb. The chemical structures of them were elaborated by extensive spectroscopic means, including 1D, 2D-NMR and HR-ESI-MS. Compound 1 is a diterpenoid derived from cembrane with a novel skeleton of 5/13 dicyclic ring system. The possible biogentic pathway of 1 was deduced. Compounds 3 and 26 exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC₅₀ value of 32.09 and 19.81 μM, respectively.

Graphical Abstract

Keywords:

• Osmjapterpenoid A
• osmunjaponin A
• Osmunda japonica thunb
• nitric oxide production

Disclosure statement

All the authors declare no conflicts of interest.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (82073737), the Open Fund of State Key Laboratory of Tea Plant Biology and Utilisation (SKLTOF20190110) and the Innovative Team of Yunnan Province (No. 2019HC018).