Hyperguanyes A and B, two new PPAPs from the branches and leaves of Hypericum perforatum L. with anti-cholinesterase activities

Abstract

Two new polycyclic polyprenylated acylphloroglucinols, hyperguanyes A and B (1–2) together with eight known compounds (3–10), were isolated from Hypericum perforatum L. Their structures were determined by using comprehensive spectroscopic techniques and quantum chemical calculation. The in vitro anti-cholinesterase activity of all compounds were studied. Among them, compounds 1–4, 8 and 9 exhibited anti-AchE and anti-BchE effects with IC₅₀ ranging from 0.34 ± 0.04 to 15.68 ± 0.54 μM.

Graphic Abstract

Keywords:

• Hypericum perforatum L
• hyperguanyes a and B
• PPAPs
• wogonin
• anti-cholinesterase activity

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Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.