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Abstract
Chlorella has a variety of biological activities, and it is worth further exploring its pharmacological effects. In this study, we investigated the antioxidant and anti-ageing activities of Chlorella polysaccharide extract (CPE). Further studies revealed that CPE exhibited anti-ageing, and antioxidant activities in vivo, including an extended Caenorhabditis elegans stress resistance, decreased deposition of lipofuscin, and reduced effects of amyloid β protein on mobility, decreased levels of reactive oxygen species and increased activity of antioxidant enzymes. Moreover, it dramatically increased the expression of anti-stress and longevity genes and reduced the expression of ageing-related genes; therefore, it was hypothesised that the mechanism of the age-delaying effect of CPE was related to the insulin signalling pathway. In summary, CPE could delay ageing and provide a new avenue for the application and development of CPE.
Graphical Abstract
Acknowledgments
The authors are greatly thankful to all those researchers whose references have been used to support this research article.
Disclosure statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Author contributions
Shu-Ting Feng and Zi-Kang Pan designed the experiment. Wen-Yi Gao and Chang-Tai You drafted the manuscript. Shu-Ting Feng and Zi-Kang Pan conducted the experiment. Shu-Ting Feng participated in analysing the result and revising the manuscript. Li-Li Hu and Ding-Ding Wang provided scientific advice. All authors have read and agreed to the published version of the manuscript.