Two new saponins from the rhizomes of Paris yunnanensis Franch

Abstract

The phytochemical investigation on the rhizomes of Paris yunnanensis Franch. resulted in the discovery and characterisation of six compounds, including two new saponins named parisyunnanosides M-N (1–2), and four known ones (3–6). The structures of isolated compounds were determined by spectroscopic data analysis and chemical methods. Compound 2 is a pregnane-type saponin with a special α,β-unsaturated carboxylic acid moiety at C-17, which is first discovered in genus Paris. The anti-inflammatory activity of the isolated compounds was assessed in vitro. The results demonstrated that compounds 3 and 4 could significantly inhibit the production of NO which was induced by LPS in RAW 264.7 cells with IC₅₀ values of 0.67 ± 0.17 μM and 0.85 ± 0.12 μM, respectively.

Graphical Abstract

Keywords:

• Paris yunnanensis Franch.
• spirostanol steroid saponins
• anti-inflammatory

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research was financially supported by National Natural Science Foundation of China (81973192), Key Research and Development Program of Shaanxi Province (2021ZDLSF04-07), Social R&D Program of Shaanxi Province (2023-YBSF-514, 2023-YBSF-170) and Project of Shaanxi Administration of Traditional Chinese Medicine (SZY-KJCYC-2023-001).