Network pharmacology-guided therapeutic exploration of a new trihydroxy fatty ester isolated from rhizomes of Trillium govanianum

Abstract

One new previously undescribed trihydroxy fatty ester (1) and three known aliphatic alkenes (2–4) have been isolated from the rhizomes of Trillium govanianum Wall. ex D.Don. The structures of isolated molecules were elucidated using extensive spectroscopic techniques including NMR, HR-ESI-MS, and FT-IR, respectively. This is the first report on the isolation of compounds 3 and 4 from the Trillium genus. Moreover, through a network pharmacology approach, the therapeutic potential of the isolated molecules was investigated. This analysis revealed that these fatty alkenes can be utilised for managing health conditions such as pneumonitis, inflammatory pain, and endothelial dysfunction.

Graphical Abstract

Keywords:

• Trillium govanianum Wall. ex D.Don
• fatty alkenes
• network pharmacology
• anti-bacterial
• anti-inflammatory agent

Acknowledgement

The authors are grateful to the Director, CSIR-IHBT for continuous encouragement and support.

Disclosure statement

The authors report no conflict of interest.

Credit authorship contribution statement

Prithvi Pal Singh conducted the isolation, characterisation, and network pharmacology analysis, and drafted the initial manuscript. Upendra Sharma designed and supervised the study, and finalised the manuscript.

Additional information

Funding

This work is supported by CSIR (FTT020503). Prithvi Pal Singh acknowledges CSIR-HRDG for Senior Research Fellowship. CSIR-IHBT communication no. for this manuscript is 5606.