Three new compounds from the fruits of Solanum virginianum L. and their anti-inflammatory activities

Abstract

Three new compounds 1-glyceryl 9(β), 10(α), 11(β)-trihydroxy-12(Z)-octadecenoate, 2’S-20-O-p-hydroxyphenylpropionyloxy-20-hyd­roxyarachidic acid glycerol ester (2), 3-O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside of ethyl (3S)-hydroxybutanoate (3), as well as a new natural product (4) were isolated from the fruits of Solanum virginianum L. The structures of 26 compounds were determined by comprehensive spectroscopic analyses, NMR calculation, chemical methods, and comparisons of spectroscopic data. Compounds 2 and 16 exhibited good anti-inflammatory activity in the LPS-induced RAW 264.7 inflammatory model with IC₅₀ values of 16.75 ± 1.54 and 22.43 ± 2.01 μM, respectively.

Graphical Abstract

Keywords:

• Aliphatic acids
• aliphatic glycosides
• anti-inflammatory
• Solanum virginianum L.
• structure identification

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Funding

Thanks for the financial support of this work by the Heilongjiang Touyan Innovation Team Program and Key Research ([2019] No. 5) and Heilongjiang Province ‘Double-First Class’ Discipline Collaborative Innovation Achievement Construction Project (LJGXCG2022-096) and Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education.