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Abstract
Pactermines E and F (1 and 2), two new pregnane alkaloids were isolated from the whole plant of Pachysandra terminalis Sieb. et Zucc. Their structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D NMR, IR, HR-ESI-MS data. Cytotoxic activities against three human cancer A549, HCT116 and SW620 cell lines of the isolated compounds were evaluated by CCK8 method. However, all compounds showed no significant activity against the three cancer cells (IC50>100 μM) except for compound 1, which showed inhibitory effects against HCT116 cells with IC50 values of 84.6 μM.
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Disclosure statement
The authors declare no competing financial interest.
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Funding
This work was supported by the National Natural Science Foundation of China (82104368), Sci-Tech Innovation Talent System Construction Program of Shaanxi University of Chinese Medicine (2023-CXTD-05) and the Shaanxi University of Chinese Medicine Graduate Innovation Practice Ability Enhancement Project (CXSJ202304). State Administration of Traditional Chinese Medicine high-level key discipline construction project (zyyzdxk-2023202).