Biological activities of selected 1-Oxo-tetrahydroisoquinolinone alkaloids

Abstract

Natural products continue to represent a compelling resource for uncovering chemical scaffolds characterised by significant structural variability and diverse biological activities. These compounds possess the potential to be directly utilised or to serve as initial templates for further refinement, ultimately leading to the development of innovative pharmaceutical agents. Among natural products, isoquinoline alkaloids stand out as one of the most extensively researched groups. 1-Oxo-tetrahydroisoquinolinones (1 O-THIQ), isolated from a variety of natural sources, exhibit valuable biological properties. This review investigates the bioactivities of specific 1 O-THIQ alkaloids, which have not been reviewed to the same depth in previous studies.

Graphical Abstract

Keywords:

• 1-Oxo-tetrahydroisoquinolinones
• natural product
• alkaloid
• biological activity
• 1O-thiq

Acknowledgment

We would like to acknowledge the support of Health Canada and the Safe Environments Directorate during the preparation of this review.

Disclosure statement

No potential conflict of interest was reported by the authors. The views expressed in this article are those of the authors and do not necessarily represent the views or the policies of the author’s employer, organisation, or other group.

Additional information

Funding

This research received no external funding.