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Abstract
Asperphenol A (1), a new isoprenyl-phenol-type meroterpenoid, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y65 together with five known compounds (2-6). All structures were assigned using extensive NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1-6 were evaluated for their cytotoxic activity against A549 and T24 human cancer cell lines. Among them, compounds 1 and 5 exhibited moderate inhibitory activities against T24 cancer cell lines with the IC50 values of 26.71 and 43.50 μM, respectively.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was supported by the Natural Science Foundation of Guangxi Province (2024GXNSFBA010005), and Basic Ability Improvement Project of Young and Middle-Aged Teachers in Guangxi Colleges (2024KY0597), the China University Students Innovative Project (202410606030), the PhD Start-up Fund of Yulin Normal University (G2023ZK22) and the National Natural Science Foundation of China (21961042, 22361046).