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Original Articles

Tympanometry in rhesus monkeys: Effects of aging and caloric restriction

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Pages 209-214 | Received 23 Apr 2007, Published online: 07 Jul 2009
 

Abstract

Caloric restriction is the only known method of increasing lifespan in laboratory animals. The present study was conducted as part of a larger investigation into the effect of caloric restriction on longevity of rhesus monkeys as a model for human aging. This study focused on the effects of caloric restriction and aging on measures of middle-ear function measured with tympanometry. Peak compensated static acoustic admittance (peak Ytm) tended to be reduced with aging. For tympanometric width (TW), the effect of age was significant with TW increasing with age. Males had a trend of narrower TW than females. A significant age by sex interaction indicated that TW for males stays relatively constant, whereas TW for females increases with age. The equivalent ear canal volume (Vea) was significantly larger in male monkeys than in female monkeys, and marginally larger for the control monkeys than for the caloric restricted monkeys. These results parallel many findings in middle-ear function in aging humans. Longitudinal studies are planned.

Abbreviations
Ytm=

Peak compensated static acoustic admittance

TW=

Tympanometric width

Vea=

Equivalent ear canal volume

Abbreviations
Ytm=

Peak compensated static acoustic admittance

TW=

Tympanometric width

Vea=

Equivalent ear canal volume

Sumario

La restricción calórica es el único método conocido para aumentar el tiempo de vida en los animales de laboratorio. Este estudio se realizó como parte de una investigación más amplia sobre el efecto de la restricción calórica en la longevidad de los monos rhesus, como modelo para el envejecimiento humano. Este estudio se enfoca en los efectos de la restricción calórica y el envejecimiento sobre la función del oído medio medida por medio de timpanometría. La admitancia acústica estática compensada (peak Ytm) tendía a reducirse con la edad. La amplitud timpanométrica (TW) aumenta significativamente como efecto de la edad. Los machos tienen una tendencia de menor TW que las hembras. Una interacción significativa de la edad versus el sexo indicó que la TW en los hombres permanece relativamente constante, mientras que la TW en las mujeres aumenta con la edad. El volumen equivalente del conducto auditivo fue significativamente mayor en monos machos que en monos hembra, y marginalmente más amplios en los monos control que en los monos bajo restricción calórica. Estos resultados son paralelos a los hallazgos sobre la función del oído medio en el envejecimiento humano. Se planean estudios longitudinales.

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