G-Octamer Formation from N⁹-Modified Guanine Derivatives

Abstract

The properties of the self-assembly of two lipophilic guanine derivatives, 2′,3′,5′-O-tris(tert-butyldimethylsilyl)-guanosine and N⁹-(3,5-bis(tert-butyldimethylsilyloxy)-benzyl)-guanine, are described. In the presence of K⁺, both guanine derivatives self-associate into D ₄-symmetric octamers consisting of two G-quartets stacked around a central ion.

Keywords:

• Guanine derivative
• G-quartet
• octamer
• self-assembly