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Nucleosides, Nucleotides & Nucleic Acids Volume 31, 2012 - Issue 3
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Original Articles

Synthesis of 2′-Substituted Inosine Analogs via Unusual Masking of the 6-Hydroxyl Group

Fabio Casu Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
,
Rebecca K. Harston Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
,
Maria A. Chiacchio Dipartimento di Scienze Chimiche, Università di Catania, viale A. Doria 6, Catania, Italy
&
Giuseppe Gumina Department of Pharmaceutical Sciences, South University School of Pharmacy, Savannah, Georgia, USA
Pages 224-235 | Received 28 Nov 2011, Accepted 13 Dec 2011, Published online: 22 Feb 2012
 
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Abstract

2′-Modified inosine analogs have been synthesized from 6-chloropurine riboside via 6-dimethylaminopurine or 6-benzyloxypurine intermediates. The dimethylaminopurine intermediate was obtained via an unusually facile dimethylamine transfer from dimethylformamide.

Graphical Abstract:

Acknowledgments

This work supported by South University School of Pharmacy and Medical University of South Carolina Institutional Research Funds.

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