Synthesis, Characterization, and Evaluation of Five Coordinated Copper(II) Complexes as Antibacterial, Artificial Nuclease, and Sod Mimics

Abstract

The copper(II) complexes with ciprofloxacin (CFLH), levofloxacin (LFLH), norfloxacin (NFLH), and neutral bidentate ligands have been synthesized and characterized. The complexes have been evaluated for their antibacterial activity against selective species. Complexes have been also checked for their interacting behavior with DNA, and were found to have two different modes of interaction, classical and partial intercalation. Tested complexes were found to be better antioxidants with their IC₅₀ values ranging from 0.51 to 0.97 μM.

Keywords:

• Square pyramidal Cu(II) complexes
• fluoroquinolone
• MIC
• intercalation mode of binding

Acknowledgments

The authors thank the Head of the Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, India for making it possible to work in the laboratory and U.G.C. for providing financial support under the “UGC Research Fellowship in Science for Meritorious Students” scheme.