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Nucleosides, Nucleotides & Nucleic Acids Volume 33, 2014 - Issue 4-6: Proceedings of the 15th International Symposium on Purine and Pyrimidine Metabolism in Man
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Miscellany

Hyperuricemia in Hematologic Malignancies Is Caused by an Insufficient Urinary Excretion

Yoko OkaDepartment of Internal Medicine, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, Japan;Department of Hematology/Oncology, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, JapanCorrespondence[email protected]
,
Haruko TashiroDepartment of Hematology/Oncology, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, Japan
,
Ryosuke SirasakiDepartment of Hematology/Oncology, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, Japan
,
Tadashi YamamotoDepartment of Hematology/Oncology, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, Japan
,
Nobu AkiyamaDepartment of Hematology/Oncology, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, Japan
,
Kazuo KawasugiDepartment of Hematology/Oncology, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, Japan
,
Naoki ShirafujiDepartment of Hematology/Oncology, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, Japan
&
Shin FujimoriDepartment of Internal Medicine, Teikyo University, School of Medicine, Kaga Itabashiku, Tokyo, Japan
 show all
Pages 434-438 | Received 22 Nov 2013, Accepted 27 Nov 2013, Published online: 18 Jun 2014
 
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Abstract

In order to elucidate the mechanism of hyperuricemia in hematologic malignancies, we have retrospectively investigated the uric acid metabolism in 418 chemotherapy-naïve patients with hematologic malignancies. Hyperuricemia was present in 116 (27.8%) of these patients on initial hospitalization. Among 65 hyperuricemic patients analyzed uric acid metabolism, six (9.2%) had overproduction type, 52 (80.0%) had underexcretion type, and seven (10.8%) had a mixed type. Fourteen patients (3.3%) developed tumor lysis syndrome in 418 patients.

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