ABSTRACT
The present study includes the exploration of new possible nucleoside mimetics based on 4-methoxy-7H-pyrrolo[2,3-d]pyrimidine carbocyclic nucleosides (4a–g), which were synthesized by 10–15 synthetic steps and characterized adequately. We report the anti-HCV activities and cytotoxicities of 4a–g. Compound 4a was analyzed by single crystal X-ray diffraction which showed some puckering in the cyclopentene ring with a 2′-endo conformation and anti-base disposition (χ = −125.7°).
Acknowledgments
This research received funding from UGC, New Delhi, India (F. No. 39-705/2010). The authors acknowledge Dr. Reddy's Institute of Life Sciences, Hyderabad for NMR/Mass Facility, Central Instrument Facility, BIT Mesra for analytical support and Agilent Technologies for X-ray data collection and structure solution. A.S. and C.B. acknowledge DST FIST support.