Abstract
An efficient, mild and rapid procedure was employed to prepare a novel series of pyridine glycosides. The protocol allows the reaction of 2-pyridone with 1,2,3,4,6-penta-O-acetyl-α-D-glucopyranose under solvent-free microwave-assisted synthesis using different solid supports. Silica gel has been found to be an efficient and environmentally friendly promoter. Structures of the new products were confirmed based on their elemental analyses and spectral data (LC-MS/MS, IR, UV, 1D- and 2D-NMR).
Acknowledgement
Support of this research from Taif University, Kingdom of Saudi Arabia, under a Research Project Grant Award 1-438-5953 is gratefully acknowledged.