Alkylation of 6-thiopurine derivatives by the Mitsunobu reaction

Abstract

Alkylation of thiopurine derivatives with alcohols by the Mitsunobu reaction are reported in moderated to good yields. The method was applied in synthesis of number of thiopurine and thiopurine ribosides derivatives.

Keywords:

• Thiopurines
• thiopurines riboside
• Mitsunobu reaction

Disclosure statement

All authors declare that they have no conflicts of interest.

Additional information

Funding

This work was supported by the by the Brazilian National Research Council (CNPq), under grant (403543/2020-7) and the Brazilian Company of Research and Industrial Innovation (EMBRAPII, under grant 015/2020).