Association of polymorphisms within P2RX4 with type 2 diabetes mellitus: a preliminary case-control study

Abstract

Objective

Type 2 diabetes mellitus (T2DM) is a complex heterogenic metabolic with a wide range of etiology. Purinergic receptors have pivotal roles in different processes and are hypothesized to have roles in the pathogenesis of T2DM.

Materials and Methods

Three hundred subjects affected by T2DM and 300 healthy subjects were genotyped by amplification refractory mutation system polymerase chain reaction (ARMS-PCR). SPSS V16.0 was recruited for statistical analysis.

Results

The findings showed that the G allele of rs25644A > G increases the risk of T2DM in our population statistically (OR = 1.51, 95% CI = 1.14–1.99, p = 0.003). This allele in some genotype models, including the dominant model, caused an increase in the risk of T2DM. The interaction of genotypes between studied variants in the P2XR4 gene increased the risk of T2DM. Haplotype analysis showed that A_rs1169727/G_rs25644 haplotype caused an increase in the risk of T2DM.

Conclusions

The findings suggest that rs25644A > G plays a role in our population’s increased risk of T2DM.

Keywords:

• P2X4 receptors
• purinergic receptors
• type 2 diabetes mellitus
• single nucleotide variants

Acknowledgment

The authors would like to thank Zahedan University of Medical Sciences for its financial support of the current study.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.