Double-Stranded Nucleic Acids in Liquid-Crystalline Dispersions as Building Blocks for Cross-Linked Supramolecular Structures

Yu. M. Yevdokimov V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Vavilova str., 32, 117984, Moscow, Russia

V. I. Salyanov V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Vavilova str., 32, 117984, Moscow, Russia

B. V. Mchedlischvili Institute of Crystallography of the Russian Academy of Sciences, Leninsky pr., 59, 11733, Moscow, Russia

V. A. Bykov Zelenograd Research Institut for Physical Problems NT-MTD Co., 103460, Moscow-Zelenograd, Russia

A. V. Belyaev Zelenograd Research Institut for Physical Problems NT-MTD Co., 103460, Moscow-Zelenograd, Russia

S. A. Saunin Zelenograd Research Institut for Physical Problems NT-MTD Co., 103460, Moscow-Zelenograd, Russia

F. Spener Institut fuer Biochemie, Westfaelische Wilhelms-Universitat Muenster, Wilhelm-Klemm str., 2, D-48149, Muenster, Germany

M. Palumbo Department of Pharmaceutical Sciences, University of Padova, via Marzolo 5, 35131, Padova, Italy

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Abstract

Double-stranded DNA fixed in a cholesteric liquid-crystalline dispersion was used for generating an ordered supramolecular structure in the presence of anthracycline and copper (II) ions. The structure is stable in a water-salt solution and does not require poly(ethyleneglycol).The ordered network can be immobilized on the surface of a polymeric film, and may collapse in the presence of biologically and pharmacologically relevant compounds. Accordingly, the DNA-based liquid-crystalline network represents the basis to obtain novel highly sensitive biosensing units

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Double-Stranded Nucleic Acids in Liquid-Crystalline Dispersions as Building Blocks for Cross-Linked Supramolecular Structures

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Double-Stranded Nucleic Acids in Liquid-Crystalline Dispersions as Building Blocks for Cross-Linked Supramolecular Structures

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