The appropriately protected C-1′-hydroxyethyl-3-hydroxypropyl-N9-adenine nucleoside was prepared from 1-pivaloyloxy-5-tert-butyldiphenylsilyloxy-3-pentanol and adenine through the Mitsunobu reaction. One of the terminal hydroxyls was converted to the phosphonomethoxy derivative and the prodrug.
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The authors thank Drs. Charlie Bugg and Claude Bennett for their encouragement throughout this work. The authors also express appreciation to Linda Kay First for preparation of this manuscript.