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Nucleosides, Nucleotides & Nucleic Acids Volume 26, 2007 - Issue 1
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Original Articles

Electrochemical Study on Behavior of EuMo2 Complex and Its Interaction With DNA

Zhifeng Li School of life Science and Chemistry, Tianshui Normal University, Tianshui, P.R. China
,
Jingwan Kang Department of Chemistry, Northwest Normal University, Lanzhou, P.R. China
&
Xiaoquan Lu Department of Chemistry, Northwest Normal University, Lanzhou, P.R. China
Pages 9-22 | Received 04 Nov 2005, Accepted 15 Jun 2006, Published online: 08 Dec 2006
 
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Abstract

The electrochemical behavior of complex EuMo2 (Mo = Morin, 2′,3,4′5,7-pentahydroxyflavone) and its interactions with calf thymus DNA were studied using cyclic voltammetry (CV) and double potential step chronocoulometry (DPSCC) at glass carbon electrode (GCE) and DNA modified GCE, respectively. Information such as diffusion coefficient (D), rate constant (k s) of EuMo2 and intrinsic binding constant (K), binding numbers (n) of bound species per DNA (bp) were obtained. EuMo2 can bind to DNA, and the binding mode is intercalation. By nonlinear fitting with Langmuir equation, a K of 1.02 × 106 M−1 and an n of 1 were obtained.

The present work was supported by a grant from the National Natural Science foundation of China (No. 20275031, 20335030) and KJCXGC-01 from Northwest Normal University

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