Asymmetric Synthesis of Novel Apio Carbocyclic Nucleoside Analogues as Potential Antiviral and Antitumor Agent

Abstract

Novel apio carbocyclic nucleosides 18–21 were asymmetrically synthesized as potential antiviral and antitumor agent, starting from D-ribose employing aldol reaction, RCM reaction and Mitsunobu reaction as key reactions.

Keywords:

• Apio carbocyclic nucleoside
• stereoselective hydroxymethylation
• ring-closing metathesis
• Mitsunobu condensation
• asymmetric synthesis

Acknowledgments

This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502).