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Nucleosides, Nucleotides & Nucleic Acids Volume 26, 2007 - Issue 6-7
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Original Articles

Some Novel Adenosine Mimics: Synthesis and Anticancer Potential against Cervical Cancer caused by Human Papilloma Virus

Sarika Sinha Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India
,
Richa Srivastava Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India
,
Bhupesh Prusty Institute of Cytology and Preventive Oncology (ICMR), Noida, India
,
B. C. Das Institute of Cytology and Preventive Oncology (ICMR), Noida, India
&
Ramendra K. Singh Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India
Pages 773-777 | Published online: 10 Dec 2007
 
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Abstract

Two novel adenosine analogs, viz. 9-(1′-β-D-arabinofuranosyl)-6-nitro-1,3-dideazapurine or Ara-NDDP (1) and 9-(5′-deoxy-5′-S-(propionic acid) (1′-β-D-ribofuranosyl) adenine or SAH analog (2), indigenously synthesized, have been found to be potential anticancer agents against cervical cancer caused by human papilloma virus.

Acknowledgments

This work was supported by grants from the University Grants Commission and Department of Science and Technology, New Delhi, Government of India.

Sarika Sinha is currently with the Department of Microbiology & Cell Biology, IISc, Bangalore, India

Richa Srivastava is currently with the Molecular Biophysics Unit, Indian Institute of Science, Bangalore - 560 012, India

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