Abstract
The chemical modification of the 2′-O-position of nucleosides proved to be of great importance for the RNA stability. Greater stability of RNA duplexes allows a longer half life in the cell and, therefore, a better effect of RNA Interference. Here we investigated the synthesis of 2′-O-aminoethyl adenosine as a cationic modified building block.
Acknowledgments
We would like to thank the “Sonderforschungsbereich 579” and the RIGHT EU-Project NoLSHB-CT-2004-005276 for financial support.