Furano- and Pyrrolo [2,3-D] Pyrimidine Nucleosides and Their 5′-O-Triphospates: Synthesis and Enzymatic Activity

Abstract

A series of bicyclic [2,3-d]furano- and pyrrolopyrimidine ribonucleosides were synthesized and converted chemically into corresponding 5′-O-triphosphates. Substrate properties of the triphosphates toward some RNA and DNA polymerases are reported

Keywords:

• Furano- and pyrrolopyrimidine ribonucleosides
• nucleoside triphosphates
• DNA and RNA polymerases

Acknowledgments

We are thankful to Dr. V.S. Prasolov (Engelhardt Institute of Molecular Biology RAS, Moscow, Russia) and Dr. E.F. Belanov (State Research Center of Virology & Biotechnology “Vektor,” Koltsovo, Novosibirsk Region, Russia) for testing of obtained compounds as antiviral agents. The work is supported by the Russian Foundation for Basic Research, projects 05-04-49492, 05-04-49500 and 04-04-49621; the program of tbe Presidium of RAS on “Molecular and Cellular Biology.”