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Nucleosides, Nucleotides & Nucleic Acids Volume 26, 2007 - Issue 10-12
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Original Articles

Synthesis and Biophysical Characterization of G-Rich Oligonucleotides Conjugated with Sugar-Phosphate Tails

J. D'Onofrio Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy
,
E. Erra Dipartimento di Chimica, Universitá degli Studi di Napoli “Federico II,”, Napoli, Italy
,
G. Di Fabio Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy
,
A. Iadonisi Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy
,
L. Petraccone Dipartimento di Chimica, Universitá degli Studi di Napoli “Federico II,”, Napoli, Italy
,
L. De Napoli Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy
,
G. Barone Dipartimento di Chimica, Universitá degli Studi di Napoli “Federico II,”, Napoli, Italy
,
J. Balzarini Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
,
C. Giancola Dipartimento di Chimica, Universitá degli Studi di Napoli “Federico II,”, Napoli, Italy
&
D. Montesarchio Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy
 show all
Pages 1225-1229 | Published online: 05 Dec 2007
 
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Abstract

A number of 5′-and 3′-glycoconjugates of the oligonucleotide 5′d(TGGGAG)3′ have been synthesized, exploiting fully automated, online phosphoramidite-based solid phase strategy, as potential anti-HIV-1 agents. The thermodynamic stability of the resulting quadruplexes has been investigated by thermal denaturation studies, via a detailed CD Q1 analysis.

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