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Nucleosides, Nucleotides & Nucleic Acids Volume 26, 2007 - Issue 10-12
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Original Articles

Synthesis of Leishmania Cap-4 Intermediates, Cap-2 and Cap-3

Magdalena Lewdorowicz Department of Biophysics, Institute of Experimental Physics, Warsaw University, Warsaw, Poland
,
Janusz Stepinski Department of Biophysics, Institute of Experimental Physics, Warsaw University, Warsaw, Poland
,
Ryszard Kierzek Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
,
Jacek Jemielity Department of Biophysics, Institute of Experimental Physics, Warsaw University, Warsaw, Poland
,
Joanna Zuberek Department of Biophysics, Institute of Experimental Physics, Warsaw University, Warsaw, Poland
,
Yael Yoffe Department of Life Sciences, Ben-Gurion University, Beer Sheva, Israel
,
Michal Shapira Department of Life Sciences, Ben-Gurion University, Beer Sheva, Israel
,
Ryszard Stolarski Department of Biophysics, Institute of Experimental Physics, Warsaw University, Warsaw, Poland
&
Edward Darzynkiewicz Department of Biophysics, Institute of Experimental Physics, Warsaw University, Warsaw, Poland
 show all
Pages 1339-1348 | Published online: 05 Dec 2007
 
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Abstract

Synthesis of Leishmania mRNA 5′-cap analogs, m 7 Gpppm 2 6 AmpAm (cap-2), and m 7 Gpppm 2 6 AmpAmpCm (cap-3) is reported. Binding affinities of those cap analogs for LeishIF4E proteins were determined using fluorescence spectroscopy. Cap-3 showed similar affinity to LeishIF4Es compared to the mature trypanosomatids cap structure (cap-4).

Supported by the Polish Ministry of Science and Higher Education, Grants No. 3 T09A 153 29 and 2 P04A 006 28 and Howard Hughes Medical Institute Grant (to E.D.) No. 55 005604.

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