Abstract
A novel furan containing phosphoramidite was synthesized and incorporated into model oligonucleotides. This glycol nucleic acid based building block contains a furan unit substituting the natural base, and can be used for post synthetic oligonucleotide modifications by orthogonal chemistries such as Schiff base formation after in situ oxidation or Diels-Alder cycloadditions.
K. Stevens thanks the University of Ghent for a position as research fellow (BOF 01115203). Support from the FWO-Vlaanderen (KAN 1.5.146.06 and KAN 1.5.186.03) is gratefully acknowledged.