Abstract
We present our studies on the ability of several different nucleotide analogs as triplex-forming oligonucleotides. The modifications tested include 4′-C-hydroxymethyl, LNA, 2′-amino-LNA and N2′-functionalized 2′-amino-LNA. Triplexes containing monomers of N2′-glycyl-functionalized 2′-amino-LNA are particularly stable.
The Danish National Research Foundation is thanked for financial support.